The Study

Author Archive | Lewis Perdue

Not All Science Is Equal. Here’s How To Assess The Value Of A Study

Grading The Strength Of Evidence (Credibility & Trust) + Complicating Factors For Different Types of Human Studies Beta Version 4.4 — 02/25/24. This presentation will be updated and/or expanded as needed. This strength-of-evidence report card was developed by Lewis Perdue. It is based upon the concept of evidence-based medicine which was developed to help clinicians […]

Continue Reading

Food and beverage sourcing and selections: background

Food selections for both legs of the study were patterned after a “typical American diet”as defined by the United States Department of Agriculture (USDA). In addition, identical (or extremely similar)  foods chosen for each leg needed to be widely available in the United States in a practical manner convenient to other investigators. Absent an unrealistically […]

Continue Reading

METHODS – Food Preparation Environment Standards

“Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs.” — The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls Develop a set […]

Continue Reading

Possibilities for Further Investigation

This n=1 trial points out two further factors to make a larger trial better able to more accurately determine causality between human clinical health indicators and BPA and other plastic-derived chemicals. This ad-free article is made possible by the financial support of the Center for Research on Environmental Chemicals in Humans: a 501(c)(3) non-profit. Please consider […]

Continue Reading

Reducing Non-Food Exposures in Dietary Intervention

Attempts can be made to reduce non-food exposures (NFEs) in dietary intervention studies. However, it is impractical (and probably impossible) to eliminate them. Plastic micro- and nanoparticles, as well as the chemical compounds used to produce, are ubiquitous in the environment and present formidable confounding factors that make it impossible to establish causal relationships between […]

Continue Reading

Playing Whack-A-Mole With Plastics And Your Health

This is a true tale for modern consumers, based upon results from a scientific paper created by the Center for Research on Environmental Chemicals In Humans. In science, as well as in classic mysteries, that which is missing often provides a pivotal clue discoverable only after a bit of detective work. In Sir Arthur Conan […]

Continue Reading

Mice Are Not People: Why The Most Important Studies Done With Them Ultimately Fail In Humans

Pharmaceutical studies are among the most demanding scientific investigations because the results can be a matter of life or death. Astonishingly, 92% of drugs deemed safe and effective in animals, fail when tested in humans. The murine model — mostly mice and sometimes rats — is invaluable in the preliminary stages of investigating pharmaceuticals and […]

Continue Reading

SSHS-Supplemental Material – Mass Spectrometry

Serum BPA and Conjugate Analysis Report_OSU 2021 Updated-LinusPauling-serumdata_10212021-1           This ad-free article is made possible by the financial support of the Center for Research on Environmental Chemicals in Humans: a 501(c)(3) non-profit. Please consider making a tax-deductible donation for continued biomedical research.

Continue Reading

The Stealth Syndromes MedRxiv Study, Revisited and Thoughts for the Future

The chart on the left was published October 27, 2020 in MedRxiv: as Investigating hsCRP as a clinical inflammation marker for human Bisphenol A food contamination offers protocol suggestions for conducting replicable, causal dietary intervention studies (doi: https://doi.org/10.1101/2020.10.25.20212282). By contrast, the chart on the right, from September 2021 mass spec data, revealed scant evidence of […]

Continue Reading