
Double blind, human study to explore the causal relationship between the measured dosed exposure of three common bisphenols, and a panel of metabolic and inflammatory clinical markers.
Following is the full consolidated text of proposed draft of study designed by Lewis Perdue and submitted to the IRB committee on human research at the University of California San Francisco School of Medicine. Funding for the study will be lead by the Center For Research on Environmental Chemicals in Humans. The U.S. Food and […]

Playing Whack-A-Mole With Plastics And Your Health
This is a true tale for modern consumers, based upon results from a scientific paper created by the Center for Research on Environmental Chemicals In Humans. In science, as well as in classic mysteries, that which is missing often provides a pivotal clue discoverable only after a bit of detective work. In Sir Arthur […]

How Strict Rules on Sourcing Dairy Proved Impossible — and Would Have Hurt Reproducibility As Well
Dairy has many opportunities for plastic contamination For dairy products, we created an ultra-strict sourcing protocol that assumed that the introduction of plastic chemicals into the dairy food chain begins with the milking process. That strict protocol had to be drastically altered will be described below. To consumers, the most obvious connection between plastic and […]

High Profile Dietary Intervention Fails to Approach Causality and Replicability
NOTE: An earlier, May 2020 look at this issue can be found here: Significant changes necessary in order for dietary intervention studies to be causal and replicable “Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the […]

Published Trial Results Indicate That All Dietary Interventions So Far Are Not Replicable. New Protocols Suggested to Assure Reproducible, Useful Results
The text as published at medRxiv is at this link: Investigating hsCRP as a clinical inflammation marker for human Bisphenol A food contamination offers protocol suggestions for conducting replicable, causal dietary intervention studies Investigating hsCRP as a clinical inflammation marker for human Bisphenol A food contamination offers protocol suggestions for conducting replicable, causal dietary intervention […]

Moving Toward the Trial: Some Final Thoughts on Procedures, Methods, Food Acquisition, and Best Practices
Developing a scientifically sound set of methods for a dietary intervention that could result in replicable, causally valid results took investigators five years of intensive effort. That was a necessary first step because no such standards, protocols, methods or best practices existed. That absence required investigators to develop those standards and protocols de novo in […]

Significant Changes Necessary in Order for Dietary Intervention Studies to be Causal and Replicable
Dietary intervention studies as a whole are inherently flawed and do not produce causal or clinically relevant health recommendations or decisions. Accuracy and replicability of any study depend upon using precise methods under identical conditions using identical materials, reagents, apparatus, and test subjects. Unfortunately, human dietary intervention studies in the scientific literature are fatally confounded […]

Dosing of a Single Compound to Establish Causality in Dietary Interventions & Enable Clinically Valid Health Decisions
“Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs.” — The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls Dietary studies are […]

Basic Scientific Lab Standards — Best Practices for a Replicable Dietary Intervention
NOTES: All of the best practices described below have been developed and hands-on tested in an actual dietary intervention study as feasible and minimally disruptive in a commercial-standard kitchen. The kitchen must be treated as a laboratory; a recipe is a protocol; foods are reagents; every item used in preparation and cooking is equipment and […]